AML-1 mutations outside the RUNT domain: description of two cases in myeloid malignancies
نویسندگان
چکیده
منابع مشابه
High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2aB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
The AML1 gene, situated in 21q22, is often rearranged in acute leukemias through t(8;21) translocation, t(12;21) translocation, or less often t(3;21) translocation. Recently, point mutations in the Runt domain of the AML1 gene have also been reported in leukemia patients. Observations for mutations of the Runt domain of the AML1 gene in bone marrow cells were made in 300 patients, including 131...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2002
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2402656